Lin Jinshun
Assitant Professor

Education

09/2008- 01/2013, Ph.D., Organic Chemistry, Tsinghua University, China
09/2005-07/2008, M.S., Medical Chemistry, Shenyang Pharmaceutical University, China
09/2001-07/2005, B.S., Pharmaceutical Engineering, Qiqihar University, China


Professional History

2018-present, Assistant Professor, Graduate School at Shenzhen, Tsinghua University

2015-2018, Postdoctoral associate, Department of chemistry, South University of Science and Technology of China (with Prof. Dr. Xin-Yuan Liu) and Dalian Institute of Chemical Physics, CAS, China (with Prof. Dr. Xingwei Li).
2013-2015, Research Fellow, Department of chemistry, South University of Science and Technology of China (with Prof. Dr. Xin-Yuan Liu)


Research Interests:

Synthesis methodology: Asymmetric radical fluoroalkyl reaction; new synthesis methods for chiral (fluorine) antitumor agents and research on their antitumor mechanisms.


Current Projects:

National Natural Science Foundation of China Youth Fund Project, Catalytic Asymmetric Aminotrifluoro(thio)methylation and Aminofluorination of Unactivated Alkenes

[1]  Jin-Shun Lin, Tao-Tao Li, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*. Chiral Br?nsted Acid-Catalyzed Dynamic Kinetic Asymmetric  Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes. Angew. Chem. Int. Ed. 2019, DOI:10.1002/anie.201900955.

[2]  Jin-Shun Lin, Tao-Tao Li, Ji-Ren Liu, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong* and Xin-Yuan Liu*. Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three Component  Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes. J. Am. Chem. Soc. 2019, 141, 1074.Highlighted in Synfacts 2019, 15, 0255.

[3]  Fu-Li Wang #, Xiao-Yang Dong, # Jin-Shun Lin, # Yang Zeng, Guang-Yuan Jiao, Qiang-Shuai Gu, Xiang-Qi Guo, Can-Liang Ma, Xin-Yuan Liu*. Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979. (# Co-first author) Highlighted in Chem 2017, 3, 919.

[4]  Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong, Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines”. Nat. Commun. 2017, 8, 14841.

[5]  Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. “A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes”. J. Am. Chem. Soc. 2016, 138, 9357. Highlighted in Synfacts, 2016, 1020. Highlighted in Chin. J. Org. Chem. 2016, 36, 2247.

[6]  Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*. “Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter”. Angew. Chem. Int. Ed. 2015, 54, 7847. Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.

[7]  Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles”. Chem. Eur. J. 2014, 20, 1332. 

[8]  Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu*. “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles”. J. Org. Chem. 2014, 79, 7084. 

[9]  Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*. “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”. Angew. Chem. Int. Ed. 2014, 53, 11890. Highlighted in Synfacts, 2014, 10, 1281.

[10]  Lin Huang, Jin-Shun Lin, Bin Tan,* and Xin-Yuan Liu*. “Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam”. ACS Catal. 2015, 5, 2826. 

[11]  Xue-Fei Li, Jin-Shun Lin, Jian Wang, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu*. “Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Radical-Initiated Aminoarylation of Alkenes”. Acta Chim. Sinica, 2018, 76, 878.

[12]  Xue-Fei Li, Jin-Shun Lin, Xin-Yuan Liu*. “Catalytic Radical Intramolecular Aminoperfluoroalkylation and Aminodifluoromethylation of Unactivated Alkenes with Fluoroalkylsulfonyl Chlorides”. Synthesis. 2017, 49, 4213.

[13]  Taotao Li, Peng Yu, Yi-Meng Du, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu*.“Dual-Catalyzed Enantioselective Remote C?H Functionalization Triggered by Radical Trifluoromethylation of Alkenes: Highly Selective Formation of C?CF3 and C?C Bonds”. J. Fluorine Chem. 2017, 203, 210.

[14]  Ping Song, Peng Yu, Jin-Shun Lin, Yang, N.-Y.; Liu, X.-Y. “Transition-Metal-Free β?C?H Bond Carbonylation of Enamides or Amides with a Trifluoromethyl Group as CO Surrogate for the Synthesis of 1,3-Oxazin-6-ones”. Org. Lett. 2017, 19, 1330.

[15]  Lin Huang, Liu Ye, Xiao-Hua Li, Zhong-Liang Li, Jin-Shun Lin, and Xin-Yuan Liu*. “Stereoselective Radical Cyclization Cascades Triggered by Addition of Diverse Radicals to Alkynes to Construct 6(5)‐6‐5 Fused Rings”. Org. Lett. 2016, 18, 5284.

[16]  Taotao Li, Peng Yu, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,* Copper-Catalyzed Redox-Triggered Remote C–H Functionalization: Highly Selective Formation of C–CF3 and C–O Bonds”. Chin. J. Chem. 2016, 34, 490.

[17]  Jin-Shun Lin, Xiuli Jin, Yiwen Bu, Deliang Cao, Nannan Zhang, Shangfu Li, Qinsheng Sun, Chunyan Tan, Chunmei Gao, Yuyang Jiang*. “Efficient Synthesis of RITA and its Analogues: Derivation of Analogues with Improved Antiproliferative Activity via Modulation of p53/miR-34a Pathway”.Org. Biomol. Chem. 2012. 10, 9734.

[18]  Jin-Shun Lin, Feng Liu, Yuyang Jiang*. “Antisense Technologies Targeting Fatty Acid Synthetic Enzymes”.Recent Pat Anti-Canc, 2012; 7, 198. 

[19]  Feng Zhu, Chu Qin, Lin Tao, Xin Liu, Zhe Shi, Xiaohua Ma, Jia Jiang, Ying Tan, Cheng Cui, Jin-Shun Lin, Chunyan Tan, Yuyang Jiang*, Yuzong Chen*. “Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting”. PNAS. 2011; 108, 12943.

[20]  Jin-Shun Lin, Weige Zhang*, Nan Jiang, et al. “Total Synthesis of Bulbophylol-B”.J. Nat. Prod. 2008; 71, 1938. 


SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017.