Zhang Ya'ou

Professional Experience & Education

Professional History:

    Dr. Zhang, a cellular and molecular biologist, graduated from Medical school of West China University of Medical Sciences and was awarded a PhD by the same university. As attending physician, associate chief physician and associate professor, she worked for West China University of Medical Sciences from 1989 to 1994. Afterwards, she got her post-doctoral training in Toronto University, and then worked as research fellow for Harvard Medical School, and University of California at San Francisco, and City University of Hong Kong. From 2004 to now, she has taught at the Graduate School at Shenzhen, Tsinghua University, first as an associate professor and now as a full professor.


    1991 Ph.D. West China University of Medical Sciences, Hematology/Oncology

    1986 M.S. West China University of Medical Sciences, Cardiovasology

    1982 M.D. West China University of Medical Sciences, Medicine

Instruction & Advising

Current Courses:

    Science & Medicine;

    Advances in Molecular & Cell Biology;

    Introduction to Medicine

Master's & Ph.D. Advising:

  1. The functions and mechanism of noncoding RNA in tumor, neurodegenerative diseases and metabolic diseases.

  2. Research and development of small nucleic acid drugs.

Research Interests

  1. The functions and mechanism of noncoding RNA in tumor, neurodegenerative diseases and metabolic diseases.

  2. Research and development of small nucleic acid drugs.

Current Projects:

  1. National Natural Science Foundation of China “PGC-1β and its intronic miRNA regulate autophagy during adipocyte differentiation”,31571400。

  2. Basic research fund of Shenzhen, “The Study on the new mechanism of Warburg effect and the methods of Tumor therapy via inhibit Warburg effect”, JCYJ20170405103953336

  3. Basic research fund of Shenzhen, “The effect of Glial cell lesion related noncoding RNAs on Alzheimer disease” JCYJ20150724173156330

  4. Special project of Suzhou-Tsinghua innovation leading action,” Study on universal nucleic acid drugs for DNA virus”, 2016SZ0312

Additional Positions

Member of a Council of Biochemical Association in Shenzhen.

Selected Publications (correspondence or first authorships):

1. Sun B, Fan P, Liao M, Zhang Y. Modeling endophilin-mediated Aβ disposal in glioma cells. Biochim Biophys Acta. 2018 Jul 4;1865(10):1385-1396.  

2. Liu L, He J, Wei X, Wan G, Lao Y, Xu W, Li Z, Hu H, Hu Z, Luo X, Wu J, Xie W, Zhang Y, Xu N. MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability. Oncogene. 2017 Oct 19;36(42):5874-5884.

3. Jiang X, Xu C, Lei F, Liao M, Wang W, Xu N, Zhang Y, Xie W. MiR-30a targets IL-1 and regulates islet functions as an inflammation buffer and response factor. Sci Rep. 2017 Jul 13;7(1):5270.

4. Wang Z, Liu Q, Lu J, Fan P, Xie W1, Qiu W, Wang F, Hu G, Zhang Y. Serine/Arginine-rich Splicing Factor 2 Modulates Herpes Simplex Virus Type 1 Replication via Regulating Viral Gene Transcriptional Activity and Pre-mRNA Splicing. J Biol Chem. 2016 Dec 16;291(51):26377-26387

5. Wang Z, Fan P,Zhao Y,Zhang S, Lu J, Xie W2, Jiang Y, Lei F, Xu N, Zhang Y.NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription. Cell Mol Life Sci. 2016 Oct 25.

6. Wu J, Lv Q, He J, Zhang H, Mei X, Cui K, Huang N, Xie W, Xu N, Zhang Y.  MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes. Cell Commun Signal. 2014 Oct 11;12:66.

7. Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, Cui K, Liao M, He J, Jiang Y, Yang BB, Xu H, Xu N, Zhang Y. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014 Jan 1;10(1):70-9.

8. Zhao HJ, Ren LL, Wang ZH, Sun TT, Yu YN, Wang YC, Yan TT, Zou W, He J, Zhang Y, Hong J, Fang JYMiR-194 deregulation contributes to colorectal carcinogenesis via targeting AKT2 pathway. Theranostics. 2014 19;4(12):1193-208

9. He J, Wu J, Xu N, Xie W, Li M, Li J, Jiang Y, Yang BB*, Zhang Y*. MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes. Nucleic Acids Res. 1;41(1):498-508. 2013

10. Liu F, Lv Q, Du WW, Li H, Yang X, Liu D, Deng Z, Ling W, Zhang Y, Yang BB. Specificity of miR-378a-5p targeting rodent fibronectin. Biochim Biophys Acta. 2013 Sep 21

11. Zhang JF, Fu WM, He ML, Xie WD, Lv Q, Wan G, Li G, Wang H, Lu G, Hu X, Jiang S, Li JN, Lin MC, Zhang Y, Kung H. MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling. RNA Biol. 2011 Sep 1;8(5).

12. Shan SW, Lee DY, Deng Z, Shatseva T, Jeyapalan Z, Du WW, Zhang Y, Xuan JW, Yee SP, Siragam V, Yang BB. MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol. 2009 Aug;11(8):1031-8.

13. Min Yang*, Yaou Zhang*, Jiehong Pan, Jiusong Sun, Jian Liu, Peter Libby, Galina K. Sukhova, Alessandro Doria, Nobuhiko Katunuma, Odile D. Peroni, Michèle Guerre-Millo, Barbara B. Kahn, Karine Clement & Guo-Ping Shi. Cathepsin L activity controls adipogenesis and glucose tolerance. Nature Cell Biology. Nat Cell Biol. 2007 Aug;9(8):970-7. (Authors contributed equally to this study)

14. Hua Z, Lv Q, Ye W, Wong CK, Cai G, Gu D, Ji Y, Zhao C, Wang J, Yang BB, Zhang Y*. MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia PLoS ONE. 2006 Dec 27;1:e116. (cited 418 times)

15. Zhang Y, Fong CC, Wong MS, Tzang CH, Lai WP, Fong WF, Sui SF, Yang M. Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress. Apoptosis. 2005 May;10(3):545-556

16. Sukhova GK*, Zhang Y*, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest 2003 Mar;111(6):897-906 (Authors contributed equally to this study)

17. Zhang Y, Song S, Fong CC, Tsang CH, Yang Z, Yang M. cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light. J Invest Dermatol 2003 May;120(5):849-57

18. Zhang, Y., Cao, L., Yang, B. L., and Yang, B. The G3 domain of versican enhances cell proliferation via epidermal growth factor-like matifs. J. Biol. Chem. 1998, 273, 21342.

19. Zhang, Y., Cao, L., Yang, B. L., and Yang, B. B. The G3 domain of versican inhibits mesenchymal chondrogenesis via the epidermal growth factor -like motifs. J. Biol. Chem. 1998, 273, 33054.

Oversees High-Caliber Personnel (Level B) in Shenzhen;

Personnel of Hundred people plan in Shenzhen.