Xu Naihan
Associate Professor

Professional Experience & Education

Professional History:

    2011-present:  Associate professor, Graduate School at Shenzhen, Tsinghua University

    2010-2011: Assistant professor, Graduate School at Shenzhen, Tsinghua University

    2007-2010: Cancer Research UK china fellow, Beatson Institute for Cancer Research

    2003-2006: Research Associate, Hong Kong University of Science and Technology

Education:

    9/1998-1/2003:   Ph.D in Biology, Hong Kong University of Science & Technology, China

    9/1995-7/1998:   M.Sc. in Biology,  Nankai University, China

    9/1991-7/1995:   B.Sc. in Biology, Hubei University, China


Instruction & Advising

Current Courses:

    1. Molecular biology of the gene

    2. Introduction to Biophysics

    3. Experimental methods in biophysics

    4. Boot camp: fundamental biology

    5. Laboratory of modern biological science and biotechnology

Master's & Ph.D. Advising:

    Autophagy, cell death and cancer biology

    Cell cycle and checkpoint control

    Novel anticancer drug discovery


Research Interests

  • Study the function of RNA-binding proteins in regulating cell cycle and checkpoint response.

  • Study the function of deubiquitinase in regulating autophagy and cancer cell metabolism.

  • Screening for novel autophagy inhibitors with anticancer potential.



1.      Liu L, He J, Wei X, Lao Y, Xu W, Li Z, Hu H, Hu Z, Luo X, Wu J, Xie W, Zhang Y#, Xu N#. MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability. Oncogene. 2017 Jun 19. doi: 10.1038/onc.2017.193.

2.      Zhao H, Qin X, Yang D, Jiang Y, Zheng W, Wang D, Tian Y, Liu Q, Xu N#, Li Z#. The development of activatable lytic peptides for targeting triple negative breast cancer. Cell Death Discov. 2017 Jul 17:3:17037. doi: 10.1038/cddiscovery.2017.37.

3.      Wu P, Xu N#, Tan C#, Liu L, Tan Y, Chen Z, Jiang Y. Light-Induced Translocation of a Conjugated Polyelectrolyte in Cells: From Fluorescent Probe to Anticancer Agent. ACS Appl Mater Interfaces. 2017 Mar 29;9(12):10512-10518.

4.      Wang Z, Fan P, Zhao Y, Zhang S, Lu J, Xie W, Jiang Y, Lei F, Xu N#, Zhang Y#. NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription. Cell Mol Life Sci. 2017 Mar;74(6):1117-1131.

5.      Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, Wu J, Xie W, Zhang Y#, Xu N#. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016 Jul 5;7(27):42274-42287.

6.      Lao Y, Xu N#. Autophagy in Cancer Chemoprevention: Identification of Novel Autophagy Modulators with Anticancer Potential. Methods Mol Biol. 2016;1379:151-63.

7.      Zhao H, Liu QS, Geng H, Tian Y, Cheng M, Jiang YH, Xie MS, Niu XG, Jiang F, Zhang YO, Lao YZ, Wu YD#, Xu NH#, Li ZG#. Crosslinked aspartic acids as helix-nucleating templates. Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12088-93.

8.      Yuan Tian, Jingxu Li, Hui Zhao, Xiangze Zeng, Dongyuan Wang, Qisong Liu, Xiaogang Niu, Xuhui Huang, Naihan Xu#, Zigang Li#. Stapling of unprotected helical peptides via photoinduced intramolecular thiol–yne hydrothiolation. Chemical Science. 2016,7,3325-3330.

9.      Wang X*, Lao Y*, Xu N*, Xi Z, Wu M, Wang H, Li X, Tan H, Sun M, Xu H#. Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins. Sci Rep. 2015 May 14;5:10293.

10.    Huang N, Wu J, Qiu W, Lyu Q, He J, Xie W, Xu N#, Zhang Y#. MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin. Cancer Biol Ther. 2015;16(6):941-8.

11.    Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA, Ryan KM. Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8.

12.    Wu J, Lv Q, He J, Zhang H, Mei X, Cui K, Huang N, Xie W, Xu N#, Zhang Y#. MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes. Cell Commun Signal. 2014 Oct 11;12:66.

13.    Lao Y, Wan G, Liu Z, Wang X, Ruan P, Xu W, Xu D, Xie W, Zhang Y, Xu H#, Xu N#. The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation. Autophagy. 2014 May;10(5):736-49.

14.    Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, Cui K, Liao M, He J, Jiang Y, Yang BB, Xu H, Xu N#, Zhang Y#. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014 Jan;10(1):70-9.

15.    He J, Wu J, Xu N, Xie W, Li M, Li J, Jiang Y, Yang BB, Zhang Y. MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes. Nucleic Acids Res. 2013 Jan 7;41(1):498-508.

16.    Xu N, Lao Y, Zhang Y, Gillespie DA. Akt: a double-edged sword in cell proliferation and genome stability. J Oncol. 2012;2012:951724.

17.    Yi C, Xie WD, Li F, Lv Q, He J, Wu J, Gu D, Xu N#, Zhang Y#. MiR-143 enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin. FEBS Lett. 2011 Oct 20;585(20):3303-9.

18.    Xu N, Libertini S, Black EJ, Lao Y, Hegarat N, Walker M, Gillespie DA. Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage. Oncogene. 2012 Mar 1;31(9):1086-94.

19.    Smith J, Tho LM, Xu N, Gillespie DA. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res. 2010;108:73-112.

20.    Xu N, Hegarat N, Black EJ, Scott MT, Hochegger H, Gillespie DA. Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2. J Cell Biol. 2010 Aug 9;190(3):297-305.


Overseas high-caliber personnel in Shenzhen, 2013-2018

Cancer Research UK China Fellowship, 2007-2010